Tsugafolin yog ib qho flavonoid, ib hom kev noj haus polyphenol pom muaj nyob hauv ntau cov nroj tsuag, suav nrog qee cov conifers, xws li Japanese cedar (Cryptomeria japonica), uas loj hlob hauv Tsuga genus. Cov kev tshawb fawb yav dhau los tau qhia tias flavonoids tuaj yeem muaj txiaj ntsig kev noj qab haus huv, suav nrog tshuaj tiv thaiv kab mob, tshuaj tua kab mob antioxidant, thiab tshuaj tiv thaiv kab mob.
Txhawm rau kuaj cov kab mob qog noj ntshav ntawm Tsugafolin, cov kws tshawb fawb tau cais qhov sib xyaw ntawm nplooj ntawm Tsuga sieboldii, tsob ntoo ntsuab ntsuab. Tom qab ntawd lawv tau sim cov tshuaj sib xyaw ua ke ntawm ntau tus tib neeg cov kab mob qog noj ntshav, suav nrog mob ntsws cancer, mob qog noj ntshav, mob qog noj ntshav, thiab mob qog noj ntshav mis. Cov txiaj ntsig tau pom tias Tsugafolin muaj lub zog cytotoxicity, lossis lub peev xwm tua cell, tawm tsam cov qog nqaij hlav cancer no, nrog IC50 qhov tseem ceeb ntawm 0.8 txog 16.9 μM.
Cov kev sim ntxiv tau qhia tias Tsugafolin induced apoptosis, lossis programmed cell tuag, hauv cov qog nqaij hlav cancer, nrog rau inhibited cell migration thiab invasion, ob qho tib si yog cov txheej txheem tseem ceeb hauv kev mob qog noj ntshav. Tsis tas li ntawd, Tsugafolin tau pom los txwv cov kev qhia ntawm ntau yam proteins koom nrog hauv txoj kev qhia txog kev mob qog noj ntshav, xws li AKT, ERK, thiab STAT3.
Qhov kev tshawb pom ntawm Tsugafolin raws li lub ntuj tsim tshuaj tiv thaiv kab mob tuaj yeem qhib txoj hauv kev tshiab rau kev kho mob qog noj ntshav thiab tiv thaiv. Tsis zoo li cov tshuaj hluavtaws, cov khoom siv ntuj tsim muaj qhov zoo ntawm feem ntau muaj kev nyab xeeb thiab ua haujlwm zoo los ntawm tib neeg lub cev, thiab tseem tuaj yeem muab cov qauv qauv tshiab rau kev tsim tshuaj. Txawm li cas los xij, xav tau kev tshawb fawb ntxiv ua ntej Tsugafolin tuaj yeem tsim kho rau hauv cov tshuaj kho mob rau kev kho mob qog noj ntshav.
